lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth

2022113 citationsJournal Articlebronze Open Access

Authors

Haobo Li · Harvard University

Lena Trager · Harvard University

Xiaojun Liu · Harvard University

Margaret H. Hastings · Harvard University

Chunyang Xiao · Harvard University

Justin Ralph Baldovino Guerra · Harvard University

Samantha To ·

Abstract

These studies identify lncExACT1-DCHS2 as a novel pathway regulating cardiac hypertrophy and cardiomyogenesis. lncExACT1-DCHS2 acts as a master switch toggling the heart between physiological and pathological growth to determine functional outcomes, providing a potentially tractable therapeutic target for harnessing the beneficial effects of exercise.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 145, Issue 16, pp. 1218-1233

DOI: 10.1161/circulationaha.121.056850

Field-Weighted Citation Impact: 10.07