Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage

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Authors

Karin L. Meeker · Washington University in St. Louis

Omar H. Butt · Washington University in St. Louis

Brian A. Gordon · Mallinckrodt (United States)

Anne M. Fagan · Washington University in St. Louis

Suzanne E. Schindler · Washington University in St. Louis

John C. Morris · Washington University in St. Louis

Tammie L.S. Benzinger

Abstract

CSF NfL is a non-specific marker of aging and white matter integrity with limited sensitivity to specific markers of AD. CSF NfL likely reflects processes associated with cerebrovascular disease.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Advanced Neuroimaging Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurobiology of Disease

Volume 166, pp. 105662-105662

DOI: 10.1016/j.nbd.2022.105662

Field-Weighted Citation Impact: 8.36