Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [<sup>11</sup>C]UCB‐J

2022173 citationsJournal Articlehybrid Open Access

Authors

Adam P. Mecca · Yale University

Ryan S. O’Dell · Yale University

Emily Sharp · Yale University

Emmie Banks · Yale University

Hugh H. Bartlett · Yale University

Wenzhen Zhao · Yale University

Sylwia Lipior · Yale University

Abstract

These results confirm neuropathologic studies demonstrating a significant association between synaptic density and cognitive performance, and suggest that this correlation extends to the early stages of AD.

Topics & Keywords

Alzheimer's disease research and treatments Functional Brain Connectivity Studies Dementia and Cognitive Impairment Research

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Alzheimer s & Dementia

Volume 18, Issue 12, pp. 2527-2536

DOI: 10.1002/alz.12582

Field-Weighted Citation Impact: 20.32