Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression

2022139 citationsJournal Articlegreen Open Access

Authors

Junhao Wen · University of Pennsylvania

Cynthia H.Y. Fu · University of East London

Duygu Tosun · University of California, San Francisco

Yogasudha Veturi · University of Pennsylvania

Zhijian Yang · University of Pennsylvania

Ahmed Abdulkadir · University of Pennsylvania

Elizabeth Mamourian

Abstract

This study characterized heterogeneity in LLD into 2 dimensions with distinct neuroanatomical, cognitive, clinical, and genetic profiles. This dimensional approach provides a potential mechanism for investigating the heterogeneity of LLD and the relevance of the latent dimensions to possible disease mechanisms, clinical outcomes, and responses to interventions.

Topics & Keywords

Dementia and Cognitive Impairment Research Functional Brain Connectivity Studies Treatment of Major Depression

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: JAMA Psychiatry

Volume 79, Issue 5, pp. 464-464

DOI: 10.1001/jamapsychiatry.2022.0020

Field-Weighted Citation Impact: 24.19