Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

2022188 citationsJournal Articlegold Open Access

Authors

Hao Liu · Xijing Hospital

Danxiu Li · Air Force Medical University

Lina Sun · Xi’an Children’s Hospital

Hongqiang Qin · Chinese Academy of Sciences

Ahui Fan · Xijing Hospital

Lingnan Meng · Xijing Hospital

Ramona Graves‐Deal · Vanderbilt University Medical Center

Abstract

MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of TCF7L2 mRNA stability. Our findings identified MIR100HG as a potent EMT inducer in CRC that may contribute to cetuximab resistance and metastasis by activation of a MIR100HG/hnRNPA2B1/TCF7L2 feedback loop.

Topics & Keywords

RNA modifications and cancer Cancer-related molecular mechanisms research RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 21, Issue 1, pp. 74-74

DOI: 10.1186/s12943-022-01555-3

Field-Weighted Citation Impact: 16.03