Parkin Deficiency Impairs Mitochondrial <scp>DNA</scp> Dynamics and Propagates Inflammation

202271 citationsJournal Articlehybrid Open Access

Authors

Kobi Wasner · University of Luxembourg

Semra Smajić · University of Luxembourg

Jenny Ghelfi · University of Luxembourg

Sylvie Delcambre · University of Luxembourg

Cesar A. Prada‐Medina · Max Planck Institute for Molecular Genetics

Evelyn Knappe · University of Lübeck

Giuseppe Arena

Abstract

Our findings suggest that parkin coregulates mitophagy, mitochondrial biogenesis, and mtDNA maintenance pathways, thereby protecting midbrain neurons from neuroinflammation and degeneration. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Topics & Keywords

Mitochondrial Function and Pathology Autophagy in Disease and Therapy Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Movement Disorders

Volume 37, Issue 7, pp. 1405-1415

DOI: 10.1002/mds.29025

Field-Weighted Citation Impact: 5.65