Longitudinal relationships of polycyclic aromatic hydrocarbons exposure and genetic susceptibility with blood lipid profiles

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Authors

Jixuan Ma · Huazhong University of Science and Technology

Xingjie Hao · Huazhong University of Science and Technology

Xiuquan Nie · Huazhong University of Science and Technology

Shijie Yang · Ministry of Ecology and Environment

Min Zhou · Huazhong University of Science and Technology

Dongming Wang · Ministry of Ecology and Environment

Bin Wang

Abstract

Our results suggest that high-level ΣOHPh exposure is associated with an average increase of LDL-C over 6 years, and those relationships can be aggravated by a higher LDL-C-genetic risk. No significant relationships were observed between other PAHs metabolites (including hydroxynaphthalene, hydroxyfluorene, and hydroxypyrene) and blood lipid changes over 6 years. Our findings emphasize the importance of preventing PAHs exposure, particularly among those with a higher genetic predisposition of hyperlipidemia.

Topics & Keywords

Fatty Acid Research and Health Birth, Development, and Health Alcohol Consumption and Health Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Environment International

Volume 164, pp. 107259-107259

DOI: 10.1016/j.envint.2022.107259

Field-Weighted Citation Impact: 4.17