Front Cover: Hypopurolides A – G, Labdane Diterpenoids from <i>Hypoestes purpurea</i> and Their Nitric Oxide Inhibitory Activity (Chem. Biodiversity 5/2022)

Front Cover. Hypoestes purpurea (Linnaeus) R. Brown Prodr., a shrub or perennial herb, mainly grow in Guangxi, Guangdong, and Hainan provinces of China, and also in Philippines. In China, this plant has been used for the treatment of tuberculosis, hemoptysis, bronchitis, diabetes, and traumatic injuries. Phytochemical investigation on the aerial part of H. purpurea in current study resulted in the discovery of seven new labdane-type diterpenoids, hypopurolides A – G (1 – 7), and one known analog, hypopurin D (8). Compound 6 was found to exhibit moderate inhibitory activity toward NO formation in LPS-treated RAW 264.7 cells as reported by L.-F. Ding et al. in their research article at 10.1002/cbdv.202200183.