Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF

2022182 citationsJournal Articlegold Open Access

Authors

Rui Li · The Affiliated Yongchuan Hospital of Chongqing Medical University

Dize Li · The Affiliated Yongchuan Hospital of Chongqing Medical University

Huanan Wang · Dalian University of Technology

Kaiwen Chen · Dalian University of Technology

Si Wang · Chongqing University

Jie Xu · Stomatological Hospital of Chongqing Medical University

Ping Ji

Abstract

GNP-Exos can effectively regulate bone immune metabolism and further promote bone healing partly through immune regulation of miR-451a, which may provide a therapeutic direction for bone repair.

Topics & Keywords

Extracellular vesicles in disease Macrophage Migration Inhibitory Factor Connective tissue disorders research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 13, Issue 1, pp. 149-149

DOI: 10.1186/s13287-022-02823-1

Field-Weighted Citation Impact: 13.98