Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

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Authors

Ruozhi Dang · The Affiliated Yongchuan Hospital of Chongqing Medical University

Mingyang Wang · The Affiliated Yongchuan Hospital of Chongqing Medical University

Xinhui Li · The Affiliated Yongchuan Hospital of Chongqing Medical University

Haiyang Wang · Stomatological Hospital of Chongqing Medical University

Lanxiang Liu · The Affiliated Yongchuan Hospital of Chongqing Medical University

Qingyuan Wu · Chongqing University

Abstract

These findings suggest that EDA possesses potent antidepressant and anxiolytic properties through Sirt1/Nrf2/HO-1/Gpx4 axis and Gpx4-mediated ferroptosis may play a key role in this effect.

Topics & Keywords

Tryptophan and brain disorders Stress Responses and Cortisol Treatment of Major Depression

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Journal of Neuroinflammation

Volume 19, Issue 1, pp. 41-41

DOI: 10.1186/s12974-022-02400-6

Field-Weighted Citation Impact: 29.30