Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues

202223 citationsJournal Articlegreen Open Access

Authors

Xiaoqing Chang · North Carolina Institute of Medicine

Jessica Palmer · Stemina Biomarker Discovery (United States)

Annie Lumen · National Center for Toxicological Research

Un Jung Lee · National Center for Toxicological Research

Patricia Ceger · North Carolina Institute of Medicine

Kamel Mansouri · National Institutes of Health

Catherine S. Sprankle

Abstract

This study highlights the importance of pharmacokinetic considerations when using in vitro assays and demonstrates the utility of the devTOX<sup>qP</sup> human stem cell-based platform to quantitatively assess a chemical's developmental toxicity potency.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Pharmaceutical studies and practices Epilepsy research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Birth Defects Research

Volume 114, Issue 16, pp. 1037-1055

DOI: 10.1002/bdr2.2019

Field-Weighted Citation Impact: 7.99