Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorptioninto body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.Keywords: Nano-medicines, Zeta potential, Drug targeting, Site-specific release, Dosage form stability