CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

2019208 citationsJournal Articlegold Open Access

Authors

Junxin Chen · Sir Run Run Shaw Hospital

Gang Liu · Sir Run Run Shaw Hospital

Yizheng Wu · Sir Run Run Shaw Hospital

Jianjun Ma · Sir Run Run Shaw Hospital

Hong-Fei Wu · Chinese People's Armed Police Force Medical College Affiliated Hospital

Ziang Xie · Sir Run Run Shaw Hospital

Shuai Chen

Abstract

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to promote chromatin remodeling and thus enhances the transcriptional activity of β-catenin/LEF1 complex, which indicates that circMYO10 may be a potential therapeutic target for osteosarcoma treatment.

Topics & Keywords

Circular RNAs in diseases MicroRNA in disease regulation Cancer-related molecular mechanisms research

Publication Details

Published in: Molecular Cancer

Volume 18, Issue 1, pp. 150-150

DOI: 10.1186/s12943-019-1076-1

Field-Weighted Citation Impact: 13.27

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CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Authors

Abstract

Topics & Keywords

Publication Details