The Reactome pathway knowledgebase

20131,952 citationsJournal Articlegold Open Access

Authors

David Croft · European Bioinformatics Institute

Antonio Fabregat · St. John's University

Robin Haw · Ontario Institute for Cancer Research

M Orlic-Milacic · Cold Spring Harbor Laboratory

Joel Weiser · Ontario Institute for Cancer Research

Guanming Wu · European Bioinformatics Institute

Michael Caudy

Abstract

Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.

Topics & Keywords

Bioinformatics and Genomic Networks Machine Learning in Bioinformatics Advanced Proteomics Techniques and Applications

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Nucleic Acids Research

Volume 42, Issue D1, pp. D472-D477

DOI: 10.1093/nar/gkt1102

Field-Weighted Citation Impact: 76.39