Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3

(Stem Cell Reports 9, 752–761; September 12, 2017) In Figure S2A of our originally published Supplemental Information, the image labeled as the ALP staining of H9-vehicle (control) hESCs was incorrectly chosen. We imaged two similar fields of H1-vehicle cells, and one of these images was saved as an H9 image by mistake, resulting in a duplication. The correct image for H9-vehicle cells now appears below. In addition, the bar graph in Figure S3E was inadvertently omitted during file conversion in preparation for publication. The correct Figure S3E panel now appears below. We apologize for these oversights. The errors do not affect any of our original conclusions.Figure S3ERelated to Figure 4, Effect of GSK126 treatment on mesenchymal lineage commitment on H9 hESCs, correctedView Large Image Figure ViewerDownload Hi-res image Download (PPT) Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3Yu et al.Stem Cell ReportsAugust 17, 2017In BriefIn this article, Wang and colleagues show that EZH2 was enriched in hESCs and was downregulated significantly in MSCs. Using GSK126, a small-molecule inhibitor of EZH2, they found that reducing H3K27me3 epigenetically promotes mesodermal differentiation of hESCs and generated more MSCs with multipotency. Full-Text PDF Open Access