Balanced Crystalloids versus Saline in Critically Ill Adults

20181,381 citationsJournal Articlebronze Open Access

Authors

Matthew W. Semler · Pulmonary and Allergy Associates

Wesley H. Self

Jonathan P. Wanderer · Biomedical Informatics Research Center Antwerp

Jesse M. Ehrenfeld · Biomedical Informatics Research Center Antwerp

Li Wang · Cancer Research And Biostatistics

Daniel W. Byrne · Cancer Research And Biostatistics

Joanna L. Stollings · West Pharmaceutical Services (United Kingdom)

Abstract

Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal dysfunction than the use of saline. (Funded by the Vanderbilt Institute for Clinical and Translational Research and others; SMART-MED and SMART-SURG ClinicalTrials.gov numbers, NCT02444988 and NCT02547779 .).

Topics & Keywords

Renal function and acid-base balance Trauma, Hemostasis, Coagulopathy, Resuscitation Electrolyte and hormonal disorders

Publication Details

Published in: New England Journal of Medicine

Volume 378, Issue 9, pp. 829-839

DOI: 10.1056/nejmoa1711584

Field-Weighted Citation Impact: 102.47

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Balanced Crystalloids versus Saline in Critically Ill Adults

Authors

Abstract

Topics & Keywords

Publication Details