BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival

2011109 citationsJournal Articlebronze Open Access

Authors

Douglas C. Marchion · Zhejiang Cancer Hospital

Hope M. Cottrill · Duke University

Yin Xiong · James A. Haley Veterans' Hospital

Ning Chen · Moffitt Cancer Center

Elona Biçaku · James A. Haley Veterans' Hospital

William J. Fulp · James A. Haley Veterans' Hospital

Nisha Bansal

Abstract

The BAD apoptosis pathway influences OVCA chemosensitivity and overall survival, likely via modulation of BAD phosphorylation. The pathway has clinical relevance as a biomarker of therapeutic response, patient survival, and as a promising therapeutic target.

Topics & Keywords

Cell death mechanisms and regulation RNA Interference and Gene Delivery PARP inhibition in cancer therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 17, Issue 19, pp. 6356-6366

DOI: 10.1158/1078-0432.ccr-11-0735

Field-Weighted Citation Impact: 2.74