Practice Guidelines for Management of the Difficult Airway

Developed by the American Society of Anesthesiologists Task Force on Difficult Airway Management: Robert A. Caplan, M.D. (Chair), Seattle, Washington; Jonathan L. Benumof, M.D., San Diego, California; Frederic A. Berry, M.D., Charlottesville, Virginia; Casey D. Blitt, M.D., Tucson, Arizona; Robert H. Bode, M.D., Boston, Massachusetts; Frederick W. Cheney, M.D., Seattle, Washington; Richard T. Connis, Ph.D., Woodinville, Washington; Orin F. Guidry, M.D., Jackson, Mississippi; David G. Nickinovich, Ph.D., Bellevue, Washington; and Andranik Ovassapian, M.D., Chicago, Illinois.Click on the links below to access all the ArticlePlus for this article.Please note that ArticlePlus files may launch a viewer application outside of your web browser.PRACTICE guidelines are systematically developed recommendations that assist the practitioner and patient in making decisions about health care. These recommendations may be adopted, modified, or rejected according to clinical needs and constraints.Practice guidelines are not intended as standards or absolute requirements. The use of practice guidelines cannot guarantee any specific outcome. Practice guidelines are subject to revision as warranted by the evolution of medical knowledge, technology, and practice. They provide basic recommendations that are supported by analysis of the current literature and by a synthesis of expert opinion, open forum commentary, and clinical feasibility data.This revision includes data published since the “Practice Guidelines for Management of the Difficult Airway” were adopted by the American Society of Anesthesiologists in 1992; it also includes data and recommendations for a wider range of management techniques than was previously addressed.A standard definition of the difficult airway cannot be identified in the available literature. For these Guidelines, a difficult airway is defined as the clinical situation in which a conventionally trained anesthesiologist experiences difficulty with face mask ventilation of the upper airway, difficulty with tracheal intubation, or both.The difficult airway represents a complex interaction between patient factors, the clinical setting, and the skills of the practitioner. Analysis of this interaction requires precise collection and communication of data. The Task Force urges clinicians and investigators to use explicit descriptions of the difficult airway. Descriptions that can be categorized or expressed as numerical values are particularly desirable, as this type of information lends itself to aggregate analysis and cross-study comparisons. Suggested descriptions include (but are not limited to):The purpose of these Guidelines is to facilitate the management of the difficult airway and to reduce the likelihood of adverse outcomes. The principal adverse outcomes associated with the difficult airway include (but are not limited to) death, brain injury, cardiopulmonary arrest, unnecessary tracheostomy, airway trauma, and damage to teeth.The primary focus of these Guidelines is the management of the difficult airway encountered during administration of anesthesia and tracheal intubation. Some aspects of the Guidelines may be relevant in other clinical contexts. The Guidelines do not represent an exhaustive consideration of all manifestations of the difficult airway or all possible approaches to management.The Guidelines are intended for use by anesthesiologists and by individuals who deliver anesthetic care and airway management under the direct supervision of an anesthesiologist. The Guidelines apply to all types of anesthetic care and airway management delivered in anesthetizing locations and is intended for all patients of all ages.The American Society of Anesthesiologists (ASA) appointed a Task Force of 10 members to (1) review the published evidence, (2) obtain the opinions of anesthesiologists selected by the Task Force as consultants, and (3) build consensus within the community of practitioners likely to be affected by the Guidelines. The Task Force included anesthesiologists in both private and academic practices from various geographic areas of the United States and consulting methodologists from the ASA Committee on Practice Parameters.These Practice Guidelines update and revise the 1993 publication of the ASA “Guidelines for Management of the Difficult Airway.”*The Task Force revised and updated the Guidelines by means of a five-step process. First, original published research studies relevant to the revision and update were reviewed and analyzed. Second, the panel of expert consultants was asked to (1) participate in a survey related to the effectiveness and safety of various methods and interventions that might be used during management of the difficult airway, and (2) review and comment on draft reports. Third, the Task Force held an open forum at a major national anesthesia meeting to solicit input from attendees on a draft of the Guidelines. Fourth, the consultants were surveyed to assess their opinions on the feasibility and financial implications of implementing the Guidelines. Finally, all of the available information was used by the Task Force to finalize the Guidelines.Evidence-based guidelines are developed by a rigorous analytic process (Appendix). To assist the reader, these Guidelines make use of several descriptive terms that are easier to understand than the technical terms and data that are used in the actual analyses. These descriptive terms are defined below.The following terms describe the strength of scientific data obtained from the scientific literature.The following terms describe the lack of available scientific evidence in the literature.The following terms describe survey responses from the consultants for any specified issue.Responses are assigned a numeric value of agree =+1, undecided = 0, or disagree =−1. The average weighted response represents the mean value for each survey item.There is insufficient published evidence to evaluate the effect of a bedside medical history on predicting the presence of a difficult airway. Similarly, there is insufficient evidence to evaluate the effect of reviewing prior medical records on predicting the presence of a difficult airway. There is suggestive evidence that some features of a patient's medical history or prior medical records may be related to the likelihood of encountering a difficult airway. This support is based on recognized associations between a difficult airway and a variety of congenital, acquired, or traumatic disease states. In addition, the Task Force believes that the description of a difficult airway on a previous anesthesia record or anesthesia document offers clinically suggestive evidence that difficulty may recur. The consultants and Task Force agree that a focused bedside medical history and a focused review of medical records may improve the detection of a difficult airway.An airway history should be conducted, whenever feasible, prior to the initiation of anesthetic care and airway management in all patients. The intent of the airway history is to detect medical, surgical, and anesthetic factors that may indicate the presence of a difficult airway. Examination of previous anesthetic records, if available in a timely manner, may yield useful information about airway management.In patients with no gross upper airway pathology or anatomical anomaly, there is insufficient published evidence to evaluate the effect of a physical examination on predicting the presence of a difficult airway. However, there are suggestive data that findings obtained from an airway physical examination may be related to the presence of a difficult airway. This support is based on recognized associations between the difficult airway and a variety of airway characteristics. The consultants and Task Force agree that an airway physical examination may improve the detection of a difficult airway.Specific features of the airway physical examination have been incorporated into rating systems intended to predict the likelihood of a difficult airway. Existing rating systems have been shown to exhibit modest sensitivity and specificity. The specific effect of the airway physical examination on outcome has not been clearly defined in the literature.There is insufficient published evidence to evaluate the predictive value of single features of the airway physical examination versus multiple features in predicting the presence of a difficult airway. The consultants and Task Force agree that prediction of a difficult airway may be improved by the assessment of multiple features. The Task Force does not regard any rating system as fail-safe.An airway physical examination should be conducted, whenever feasible, prior to the initiation of anesthetic care and airway management in all patients. The intent of this examination is to detect physical characteristics that may indicate the presence of a difficult airway. Multiple airway features should be assessed (table 1).The airway history or physical examination may provide indications for additional diagnostic testing in some patients. The literature suggests that certain diagnostic tests may identify features associated with a difficult airway. The literature does not provide a basis for using specific diagnostic tests as routine screening tools in the evaluation of the difficult airway.Additional evaluation may be indicated in some patients to characterize the likelihood or nature of the anticipated airway difficulty. The findings of the airway history and physical examination may be useful in guiding the selection of specific diagnostic tests and consultation.The literature is silent regarding the benefits of informing the patient of a known or suspected difficult airway, the availability of equipment for difficult airway management, or the availability of an individual to provide assistance when a difficult airway is encountered. However, there is strong agreement among consultants that preparatory efforts enhance success and minimize risk.The literature suggests that either traditional preoxygenation (3 or more minutes of tidal volume ventilation) or fast-track preoxygenation (i.e. , four maximal breaths in 30 s) is effective in delaying arterial desaturation during subsequent apnea. The literature supports the greater efficacy of traditional preoxygenation when compared to fast-track preoxygenation in delaying arterial desaturation during apnea.The literature supports the efficacy of supplemental oxygen in reducing hypoxemia after extubation of the trachea.At least one portable storage unit that contains specialized equipment for difficult airway management should be readily available. Specialized equipment suggested by the Task Force is listed in table 2.If a difficult airway is known or suspected, the anesthesiologist shouldThe literature suggests that the use of specific strategies facilitates the intubation of the difficult airway. Although the degree of benefit for any specific strategy cannot be determined from the literature, there is strong agreement among consultants that a preplanned strategy may lead to improved outcome.Preplanned strategies can be linked together to form airway management algorithms . The Task Force considers the technical and physiologic complexity of life-threatening airway events to be sufficiently similar to life-threatening cardiac events to encourage the use of algorithms in difficult airway management.The anesthesiologist should have a preformulated strategy for intubation of the difficult airway. The algorithm shown in figure 1is a strategy recommended by the Task Force. This strategy will depend, in part, on the anticipated surgery, the condition of the patient, and the skills and preferences of the anesthesiologist.The strategy for intubation of the difficult airway should includeThe literature does not provide a sufficient basis for evaluating the benefits of an extubation strategy for the difficult airway. The Task Force regards the concept of an extubation strategy as a logical extension of the intubation strategy. Consultant opinion strongly supports the use of an extubation strategy.The anesthesiologist should have a preformulated strategy for extubation of the difficult airway. This strategy will depend, in part, on the surgery, the condition of the patient, and the skills and preferences of the anesthesiologist.The preformulated extubation strategy should includeAlthough the literature is insufficient to evaluate the benefits of follow-up care, this activity is strongly supported by consultant opinion. The Task Force has identified several fundamental concepts that merit consideration.The anesthesiologist should document the presence and nature of the airway difficulty in the medical record. The intent of this documentation is to guide and facilitate the delivery of future care. Aspects of documentation that may prove helpful include (but are not limited to)The anesthesiologist should inform the patient (or responsible person) of the airway difficulty that was encountered. The intent of this communication is to provide the patient (or responsible person) with a role in guiding and facilitating the delivery of future care. The information conveyed may include (but is not limited to) the presence of a difficult airway, the apparent reasons for difficulty, how the intubation was accomplished, and the implications for future care. Notification systems, such as a written report or letter to the patient, a written report in the medical chart, communication with the patient's surgeon or primary caregiver, a notification bracelet or equivalent identification device, or chart flags, may be considered.The anesthesiologist should evaluate and follow up with the patient for potential complications of difficult airway management. These complications include (but are not limited to) edema, bleeding, tracheal and esophageal perforation, pneumothorax, and aspiration. The patient should be advised of the potential clinical signs and symptoms associated with life-threatening complications of difficult airway management. These signs and symptoms include (but are not limited to) sore throat, pain or swelling of the face and neck, chest pain, subcutaneous emphysema, and difficulty swallowing.The scientific assessment of these Guidelines was based on the following statements or evidence linkages. These linkages represent directional statements about relationships between clinical care and clinical outcome in difficult airway management.Scientific evidence was derived from aggregated research literature and from surveys, open presentations, and other consensus-oriented activities. †For purposes of literature aggregation, potentially relevant clinical studies were identified via electronic and manual searches of the literature. The electronic search covered a 37-yr period, from 1966 through 2002. The manual search covered a 60-yr period, from 1943 through 2002. More than 3,000 citations were initially identified, yielding a total of 1,106 non-overlapping articles that addressed topics related to the 30 evidence linkages. After review of the articles, 538 studies did not provide direct evidence and were subsequently eliminated. A total of 569 articles contained direct linkage-related evidence. Of these, 255 articles either used or included subjects with difficult airways.A directional result for each study was initially determined by a literature count, classifying each outcome as either supporting a linkage, refuting a linkage, or neutral. The results were then summarized to obtain a directional assessment of support for each linkage, with the intent of conducting meta-analyses where appropriate. Summary statistics for selected outcomes commonly reported in the literature are shown in table 4. These descriptive statistics separate the reported outcome data for difficult and nondifficult airway subjects.There was an insufficient number of acceptable studies to conduct a meta-analysis for the difficult airway. ‡However, two evidence linkages contained studies pertinent to the Guidelines with sufficient statistical information to conduct formal meta-analyses. These two linkages were as follows: linkage 2 days (preanesthetic preoxygenation for 3 min vs. 4 maximal breaths) and linkage 6b (supplemental oxygen delivery by mask, blow-by, or nasal cannulae after extubation of the trachea).Weighted mean effect sizes were determined for continuous outcome measures, and Mantel–Haenszel odds ratios were determined for dichotomous outcome measures. An acceptable significance level was set at P < 0.01 (one-tailed). Tests for heterogeneity of the independent studies were conducted to assure consistency among the study results. DerSimonian–Laird random-effects odds ratios were considered when significant heterogeneity was found. To control for potential publishing bias, a “fail-safe N” value was calculated. No search for unpublished studies was conducted, and no reliability tests for locating research results were performed. For time to desaturation, the weighted mean effect size was d = 1.57 (CI, 0.98–2.14) for linkage 2 days (preanesthetic preoxygenation for 3 min vs. 4 maximal breaths). For reduced frequency of hypoxemia, the fixed-effects odds ratio was 5.98 (CI, 3.16–11.31) for linkage 6b (supplemental oxygen delivery by mask, blow-by, or nasal cannulae after extubation of the trachea).Interobserver agreement among Task Force members and two methodologists was established by interrater reliability testing. Agreement levels using a kappa (κ) statistic for two-rater agreement pairs were as follows: (1) type of study design, κ= 0.64–0.78; (2) type of analysis, κ= 0.78–0.85; (3) evidence linkage assignment, κ= 0.89–0.95; and (4) literature inclusion for database, κ= 0.62–1.00. Three-rater chance-corrected agreement values were as follows: (1) study design, Sav = 0.73, Var (Sav) = 0.008; (2) type of analysis, Sav = 0.80, Var (Sav) = 0.008; (3) linkage assignment, Sav = 0.93, Var (Sav) = 0.003; and (4) literature database inclusion, Sav = 0.80, Var (Sav) = 0.032. These values represent moderate to high levels of agreement.The findings from the literature were supplemented by the opinions of Task Force members, as well as by surveys of the opinions of 50 anesthesiologists selected as consultants on the basis of their recognized interest in airway management. The κ statistic was used to obtain a quantitative measure of agreement among consultants. Consultants exhibited strong agreement (κ≥ 0.75) on the potential beneficial effects of the following activities: conduct of the airway history and physical examination, advance preparation of the patient and equipment, formulation of strategies for intubation and extubation of the difficult airway, and provision of follow-up care.