Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli

2013139 citationsJournal Articlebronze Open Access

Authors

Michael Wacker

Linhui Wang · Dalian University of Technology

Michael Kowarik

Meghan Dowd · Brigham and Women's Hospital

Gerd Lipowsky

Amir Faridmoayer

Kelly Shields · Brigham and Women's Hospital

Saeyoung Park · Brigham and Women's Hospital

Cristina Alaimo

Abstract

Glycoengineering technology, whereby polysaccharide and protein antigens are enzymatically linked in a simple E. coli production system, has broad applicability for use in vaccine development against encapsulated microbial pathogens.

Topics & Keywords

Antimicrobial Resistance in Staphylococcus Bacteriophages and microbial interactions Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 209, Issue 10, pp. 1551-1561

DOI: 10.1093/infdis/jit800

Field-Weighted Citation Impact: 6.25