Single agent versus combination chemotherapy for metastatic breast cancer

2005118 citationsReview

Authors

Sue Carrick · Breast Cancer Trials

Sharon K. Parker · National Health and Medical Research Council

Charlene Thornton · University of Sydney

Davina Ghersi · National Health and Medical Research Council

John Simes · University of Sydney

Nicholas Wilcken · Nepean Hospital

Abstract

Compared with single-chemotherapy agents, combination regimens show a statistically significant advantage for tumor response and time to progression in women with metastatic breast cancer, a modest improvement in overall survival and significantly worse toxicities.

Topics & Keywords

Cancer Treatment and Pharmacology Breast Cancer Treatment Studies Chemotherapy-related skin toxicity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cochrane Database of Systematic Reviews

DOI: 10.1002/14651858.cd003372.pub2