Differential gene expression in response to ventricular unloading in rat and human myocardium

20050 citationsJournal Article

Authors

B Barleon · National Center for Tumor Diseases

D Marme · National Center for Tumor Diseases

Friedhelm Beyersdorf · University of Freiburg

Abstract

Objectives: Left ventricular unlaoding by mechanical assist devices induces mycardial atrophy. We aimed to systematically identify differentially expressed myocardial genes in a model of physiological atrophy (unloading of healthy rat myocardium) and compare these changes to those in unloaded, failing human heart.

Topics & Keywords

Mechanical Circulatory Support Devices Prosthetics and Rehabilitation Robotics Cardiac Structural Anomalies and Repair

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: The Thoracic and Cardiovascular Surgeon

Volume 53, Issue S 01

DOI: 10.1055/s-2005-862065

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