P11.10: A core outcome set for studies investigating the management of selective fetal growth restriction in twins

The best treatment of selective fetal growth restriction (sFGR) in monochorionic twins is not yet known. New trials in this area are urgently needed, but in this rare and complex group maximising the relevance and utility of clinical research design and outputs is paramount. A core outcome set ensures standardised outcome collection and reporting in future research. The objective of this study was to develop a core outcome set for studies evaluating treatments for sFGR. We established an international steering group of clinicians, researchers and patients to oversee the process of core outcome set development. Outcomes reported in the literature were identified through a systematic review and informed the design of a three round Delphi survey. Clinicians, researchers and patients and family representatives participated in the survey. An international meeting of stakeholders used the modified nominal group technique to consider the consensus outcomes and agree a final core outcome set. 96 outcomes were identified from 39 studies in the systematic review. 120 participants from 23 countries completed the first round of the Delphi survey. 88 completed all three rounds. 29 outcomes met the a priori criteria for consensus and were prioritised using the modified nominal group technique. 11 core outcomes were agreed. These were live birth, gestational age at birth, birth weight, inter-twin birthweight discordance, death of surviving twin after death of co-twin, loss during pregnancy or before final hospital discharge, parental stress, procedure-related adverse maternal outcome, offspring length of stay in hospital, neurological abnormalities on postnatal imaging and childhood disability. This core outcome set represents the consensus of a large and diverse group of international collaborators. Use of these outcomes in future trials will help to increase the clinical relevance of the research. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.