TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

2022156 citationsJournal Articlegold Open Access

Authors

Ming Chi · China Medical University

Jiao Liu · First Hospital of China Medical University

Chenxue Mei · China Medical University

Yaxing Shi · Sheng Jing Hospital

Nanqi Liu · China Medical University

Xuefeng Jiang · China Medical University

Chang Liu ·

Abstract

TEAD4 is closely correlated with poor prognosis in BLCA and mediates its metastasis through regulating EMT via PI3K/AKT pathway, proving that TEAD4 is not only an effective biomarker for predicting the prognosis but also a great potential target for treatment of metastatic BLCA.

Topics & Keywords

Bladder and Urothelial Cancer Treatments Ferroptosis and cancer prognosis Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 41, Issue 1, pp. 175-175

DOI: 10.1186/s13046-022-02377-3

Field-Weighted Citation Impact: 34.04