Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

2022166 citationsJournal Articlehybrid Open Access

Authors

Hiroki Murai · The University of Osaka

Takahiro Kodama · The University of Osaka

Kazuki Maesaka · The University of Osaka

Shoichiro Tange · Sapporo Medical University

Daisuke Motooka · The University of Osaka

Yutaka Suzuki · The University of Tokyo

Yasuyuki Shigematsu ·

Abstract

Multiomics stratified nonviral HCCs according to prognosis or TIME. We identified the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible TIME.

Topics & Keywords

Ferroptosis and cancer prognosis Cancer Immunotherapy and Biomarkers Hepatocellular Carcinoma Treatment and Prognosis

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Hepatology

Volume 77, Issue 1, pp. 77-91

DOI: 10.1002/hep.32573

Field-Weighted Citation Impact: 23.71