Novel roles of METTL1/WDR4 in tumor via m7G methylation

As one of the prevalent posttranscriptional modifications of RNA, N⁷-methylguanosine (m⁷G) plays essential roles in RNA processing, metabolism, and function, mainly regulated by the methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) complex. Emerging evidence suggests that the METTL1/WDR4 complex promoted or inhibited the processes of many tumors, including head and neck, lung, liver, colon, bladder cancer, and teratoma, dependent on close m⁷G methylation modification of tRNA or microRNA (miRNA). Therefore, METTL1 and m⁷G modification can be used as biomarkers or potential intervention targets, providing new possibilities for early diagnosis and treatment of tumors. This review will mainly focus on the mechanisms of METTL1/WDR4 via m⁷G in tumorigenesis and the corresponding detection methods.