The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

202288 citationsJournal Articlegold Open Access

Authors

Liang Kou · Huazhong University of Science and Technology

Xiaosa Chi · Union Hospital

Yadi Sun · Huazhong University of Science and Technology

Chao Han · University of Science and Technology of China

Fang Wan · Union Hospital

Junjie Hu · Huazhong University of Science and Technology

Sijia Yin

Abstract

These observations suggest that the circadian clock protein Rev-erbα plays an essential role in attenuating neuroinflammation in PD pathology, and provides a potential therapeutic target for PD treatment.

Topics & Keywords

Circadian rhythm and melatonin Sleep and Wakefulness Research Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 19, Issue 1, pp. 133-133

DOI: 10.1186/s12974-022-02494-y

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