A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes

2022135 citationsJournal Articlehybrid Open Access

Authors

Abstract

After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

Topics & Keywords

Fluorine in Organic Chemistry Carbohydrate Chemistry and Synthesis Synthesis and Catalytic Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Angewandte Chemie International Edition

Volume 61, Issue 29, pp. e202205103-e202205103

DOI: 10.1002/anie.202205103

Field-Weighted Citation Impact: 10.91