Microglial amyloid beta clearance is driven by PIEZO1 channels

2022139 citationsJournal Articlegold Open Access

Authors

Henna Jäntti · University of Eastern Finland

Valeriia Sitnikova · University of Eastern Finland

Yevheniia Ishchenko · Yale University

Anastasia Shakirzyanova · University of Eastern Finland

Luca Giudice · University of Verona

Irene F. Ugidos · University of Eastern Finland

Mireia Gómez‐Budia

Abstract

These results indicate that the compromised function of microglia in AD could be improved by controlled activation of PIEZO1 channels resulting in alleviated Aβ burden. Pharmacological regulation of these mechanoreceptors in microglia could represent a novel therapeutic paradigm for AD.

Topics & Keywords

Erythrocyte Function and Pathophysiology Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 19, Issue 1, pp. 147-147

DOI: 10.1186/s12974-022-02486-y

Field-Weighted Citation Impact: 14.98