CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma

2022196 citationsJournal Articlegold Open Access

Authors

Lianyong Liu · Punan Hospital

Mingjun Gu · Shanghai Pudong New Area Gongli Hospital

Junhua Ma · Second Military Medical University

Ying Wang · Shanghai Pudong New Area Gongli Hospital

Miao Li · Fudan University

Hui Wang

Xin Yin · Fudan University

Abstract

Our results demonstrate that circGPR137B inhibits HCC tumorigenesis and metastasis through the circGPR137B/miR-4739/FTO feedback loop. This positive feedback mechanism executed by functional coupling between a circRNA sponge and an m<sup>6</sup>A modification event suggests a model for epigenetics.

Topics & Keywords

Circular RNAs in diseases RNA modifications and cancer MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 21, Issue 1, pp. 149-149

DOI: 10.1186/s12943-022-01619-4

Field-Weighted Citation Impact: 16.72