Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease

2022237 citationsJournal Articlebronze Open Access

Authors

Hongliang Xue · Sun Yat-sen University

Xu Chen · German Cancer Research Center

Chao Yu · Sun Yat-sen University

Yuqing Deng · Sun Yat-sen University

Yuan Zhang · Third Affiliated Hospital of Guangzhou Medical University

Chen Shen · Hsin Sheng College of Medical Care and Management

Xuechen Chen

Abstract

Our study identify a previously unknown link between specific gut microbiota-derived tryptophan metabolite and ASCVD. The microbial metabolite IPA/miR-142-5p/ABCA1 pathway may represent a promising therapeutic target for ASCVD.

Topics & Keywords

Diet and metabolism studies Metabolomics and Mass Spectrometry Studies Gut microbiota and health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 131, Issue 5, pp. 404-420

DOI: 10.1161/circresaha.122.321253

Field-Weighted Citation Impact: 24.64

Command Palette