Donor Macrophages Modulate Rejection After Heart Transplantation

202262 citationsJournal Articlegreen Open Access

Authors

Benjamin J. Kopecky · Washington University in St. Louis

Hao Dun · Washington University in St. Louis

Junedh Amrute · Washington University in St. Louis

Chieh‐Yu Lin · Washington University in St. Louis

Andrea Bredemeyer · Washington University in St. Louis

Yuriko Terada · Teradata (United Kingdom)

Peter O. Bayguinov

Abstract

Distinct populations of donor and recipient macrophages coexist within the transplanted heart. Donor CCR2<sup>+</sup> macrophages are key mediators of allograft rejection, and deletion of MYD88 signaling in donor macrophages is sufficient to suppress rejection and extend allograft survival. This highlights the therapeutic potential of donor heart-based interventions.

Topics & Keywords

Transplantation: Methods and Outcomes Renal Transplantation Outcomes and Treatments Organ Transplantation Techniques and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 146, Issue 8, pp. 623-638

DOI: 10.1161/circulationaha.121.057400

Field-Weighted Citation Impact: 12.27