PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism

202299 citationsJournal Articlegold Open Access

Authors

Weixing Dai · Shanghai Medical College of Fudan University

Wenqiang Xiang · Shanghai Medical College of Fudan University

Lingyu Han · Shanghai Medical College of Fudan University

Zixu Yuan · Sun Yat-sen University

Renjie Wang · Shanghai Medical College of Fudan University

Yanlei Ma · Shanghai Medical College of Fudan University

Yongzhi Yang

Abstract

PTPRO could suppress CRC development and metastasis via modulating the AKT/mTOR/SREBP1/ACC1 and MAPK/PPARα/ACOX1 pathways and reprogramming lipid metabolism.

Topics & Keywords

Cancer, Lipids, and Metabolism Cancer, Hypoxia, and Metabolism Protein Tyrosine Phosphatases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Communications

Volume 42, Issue 9, pp. 848-867

DOI: 10.1002/cac2.12341

Field-Weighted Citation Impact: 8.45