Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

20193 citationsJournal Articlegreen Open Access

Authors

van Marion,Denise · Biobase (Germany)

Xiao Hu · Amsterdam UMC Location Vrije Universiteit Amsterdam

Zhang,Deli · Amsterdam UMC Location Vrije Universiteit Amsterdam

F Hoogstra-Berends · University Medical Center Groningen

Seerden,Jean-Paul · Amsterdam UMC Location Vrije Universiteit Amsterdam

Loen,Lizette · syncom

Heeres,Andre · syncom

Abstract

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA. Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

Topics & Keywords

Heat shock proteins research

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Data Archiving and Networked Services (DANS)

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