Microglial Activation and Connectivity in Alzheimer Disease and Aging

202257 citationsJournal Articlehybrid Open Access

Authors

Boris‐Stephan Rauchmann · German Center for Neurodegenerative Diseases

Matthias Brendel · Munich Cluster for Systems Neurology

Nicolai Franzmeier · Ludwig-Maximilians-Universität München

Lena Trappmann · Ludwig-Maximilians-Universität München

Mirlind Zaganjori · Ludwig-Maximilians-Universität München

Ersin Ersoezlue · Ludwig-Maximilians-Universität München

Estrella Morenas‐Rodríguez

Abstract

Microglial activation distributes preferentially along highly connected brain regions, similar to tau pathology. These findings support the important role of microglia in neurodegeneration, and we speculate that pathology spreads throughout the brain along vulnerable connectivity pathways. ANN NEUROL 2022;92:768-781.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 92, Issue 5, pp. 768-781

DOI: 10.1002/ana.26465

Field-Weighted Citation Impact: 4.44