A first update on mapping the human genetic architecture of COVID-19

2022168 citationsletterhybrid Open Access

Authors

COVID-19 Host Genetics Initiative · Yale University

COVID-19 Host Genetics Initiative · Institute for Molecular Medicine Finland

Leadership · Broad Institute

Gita A. Pathak · Broad Institute

Juha Karjalainen · Institute for Molecular Medicine Finland

Christine Stevens · Broad Institute

Benjamin M. Neale · Broad Institute

Abstract

The COVID-19 pandemic continues to pose a major public health threat,\nespecially in countries with low vaccination rates. To better understand\nthe biological underpinnings of SARS-CoV-2 infection and COVID-19\nseverity, we formed the COVID-19 Host Genetics Initiative1\n. Here we\npresent a genome-wide association study meta-analysis of up to 125,584\ncases and over 2.5 million control individuals across 60 studies from\n25 countries, adding 11 genome-wide significant loci compared with\nthose previously identified2\n. Genes at new loci, including SFTPD, MUC5B\nand ACE2, reveal compelling insights regarding disease susceptibility\nand severity

Topics & Keywords

SARS-CoV-2 and COVID-19 Research Genomics and Rare Diseases Genetics and Neurodevelopmental Disorders

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Nature

Volume 608, Issue 7921, pp. E1-E10

DOI: 10.1038/s41586-022-04826-7

Field-Weighted Citation Impact: 16.70