Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts

2022176 citationsJournal Articlebronze Open Access

Authors

Jiajia Jin · Chinese Academy of Medical Sciences & Peking Union Medical College

Liaomei Gao · Shandong Provincial Hospital

Xiuli Zou · Liaocheng People's Hospital

Yun Zhang · Chinese Academy of Medical Sciences & Peking Union Medical College

Zhijian Zheng · Chinese Academy of Medical Sciences & Peking Union Medical College

Xinjie Zhang · Xinxiang University

Jiaxuan Li

Abstract

Our study revealed that gut microbiota dysbiosis is an important etiology of preeclampsia. Gut microbiota and their active metabolites have great potential for the treatment and diagnosis of preeclampsia. Our findings enrich the gut-placenta axis theory and contribute to the development of microecological products for preeclampsia.

Topics & Keywords

Gut microbiota and health Pregnancy and preeclampsia studies Birth, Development, and Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 131, Issue 6, pp. 492-506

DOI: 10.1161/circresaha.122.320771

Field-Weighted Citation Impact: 13.95