The associations between modifiable risk factors and nonalcoholic fatty liver disease: A comprehensive Mendelian randomization study

2022237 citationsJournal Article

Authors

Jiarong Xie · National Clinical Research Center for Digestive Diseases

Hangkai Huang · First Affiliated Hospital Zhejiang University

Zhening Liu · First Affiliated Hospital Zhejiang University

Youming Li · First Affiliated Hospital Zhejiang University

Chaohui Yu · National Clinical Research Center for Digestive Diseases

Lei Xu · First Affiliated Hospital Zhejiang University

Abstract

Genetically predicted alcohol frequency, elevated serum liver enzymes, poor physical condition, obesity traits, T2DM, and hypertension were associated with an increased risk of NAFLD, whereas higher education and HDL-cholesterol were associated with a decreased risk of NAFLD.

Topics & Keywords

Liver Disease Diagnosis and Treatment Diet, Metabolism, and Disease Genetic Associations and Epidemiology

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Hepatology

Volume 77, Issue 3, pp. 949-964

DOI: 10.1002/hep.32728

Field-Weighted Citation Impact: 37.25