Urine eosinophil‐derived neurotoxin: A potential marker of activity in select eosinophilic disorders

202220 citationsJournal Articlegreen Open Access

Authors

Michelle Makiya · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Paneez Khoury · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Fei Li Kuang · Northwestern University

Alexis Dominique Mata · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Sana Mahmood · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Abbie Bowman · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Abstract

Measurement of EGP in urine is noninvasive and unaffected by cellular lysis. Although plasma and urine EDN concentrations showed a similar pattern following benralizumab and mepolizumab treatment, the lack of correlation between AEC or prednisone dose and uEDN concentrations suggests that measurement of uEDN may provide a potential biomarker of disease activity in patients with HES and EGPA.

Topics & Keywords

Eosinophilic Disorders and Syndromes Eosinophilic Esophagitis Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Allergy

Volume 78, Issue 1, pp. 258-269

DOI: 10.1111/all.15481

Field-Weighted Citation Impact: 3.23