Progress and Development of Three Types of Live Attenuated Vaccines for Dengue Fever

Dengue fever is a disease spread by mosquitoes infected with the dengue virus (DENV) that bite people. It is produced by any of the four serotypes of DENV. Dengue fever has become one of the most widespread mosquito-borne infectious diseases in the world. According to the World Health Organization (WHO) dengue fever is a serious global public health concern. To suppress the spread of dengue fever and reduce the social, medical, and economic burden brought by dengue fever, vaccination is an effective measure to prevent the disease. Research teams around the world have worked on the development of a dengue vaccine for many years. At present, three live attenuated vaccines have made great progress and entered the final stage of clinical trials. In order to enable dengue vaccine researchers to grasp the latest research status and promote faster development of the dengue vaccine, this paper provided a comprehensive overview of the research progress of three different live attenuated vaccines: CYD-TDV, TAK-003, and TV003/005.