Synthesis, IR, and NMR Study of Some Cu(II), Ni(II), Co(II) Complexes of O-Vanillin and 2- Amino Pyridine.

In the present work the study of antimicrobial activity of ligand N(3-ethoxy-2-hyroxybenzylidine)-pyridine-2-amine, and its metal complexes was investigated. Ligand (L4) was synthesized by condensation of 2- aminopyridine and o-vanillin and by making some alterations in the previous method, synthesis of Cu(II), Co(II), and Ni(II) complexes was also carried out. The structure of the synthesised complexes has been defined using microanalysis, conductivity measurement, electronic spectra, IR spectra, and NMR spectra. It has been observed that the activity of complexes was more towards staphylococcus aureus, bacillus subtitles, Escherichia coli, and klebsiella pneumonia in comparison to the ligand. It was noticed that the presence of OCH3 group magnifies the antibacterial as well as antifungal activity of the ligand.