Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart

202264 citationsJournal Articlegreen Open Access

Authors

Prachi Umbarkar · Twitter (United States)

Sultan Tousif · University of Alabama at Birmingham

Anand Prakash Singh · Twitter (United States)

Joshua C. Anderson · University of Alabama at Birmingham

Qinkun Zhang · University of Alabama at Birmingham

Michelle D. Tallquist · University of Hawaii System

James R. Woodgett

Abstract

GSK-3α-mediated MEK-ERK activation is a critical profibrotic signaling circuit in the injured heart, which operates independently of the canonical TGF-β1-SMAD3 pathway. Therefore, strategies to inhibit the GSK-3α-MEK-ERK signaling circuit could prevent adverse fibrosis in diseased hearts.

Topics & Keywords

Cardiac Fibrosis and Remodeling Cardiac Structural Anomalies and Repair Signaling Pathways in Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 131, Issue 7, pp. 620-636

DOI: 10.1161/circresaha.122.321431

Field-Weighted Citation Impact: 10.51