Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway

2022137 citationsJournal Articlehybrid Open Access

Authors

Ruijin Xie · Jiangnan University

Wenjing Zhao · Jiangnan University

Scott Lowe · Kansas City University

Robert F. Bentley · Kansas City University

Guoqin Hu · Jiangnan University

Huiya Mei · Jiangnan University

Xiaofan Jiang · Jiangnan University

Abstract

These findings indicated that quercetin effectively protects against seizure-induced neuron death in vivo and in vitro and alleviates cognitive function impairment via the SIRT1/Nrf2/SLC7A11/GPX4 pathway.

Topics & Keywords

Ferroptosis and cancer prognosis MicroRNA in disease regulation Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Free Radical Biology and Medicine

Volume 191, pp. 212-226

DOI: 10.1016/j.freeradbiomed.2022.09.001

Field-Weighted Citation Impact: 20.22