Comparison between a dual-time-window protocol and other simplified protocols for dynamic total-body 18F-FDG PET imaging

Using the DTW protocol, the dynamic total-body FDG scan time can be reduced to 15 min while obtaining accurate K_i and K₁ quantification and acceptable visual performance in parametric images. However, the trade-off between quantification accuracy and protocol implementation feasibility must be considered in practice. We recommend that the DTW protocol be used when the clinical task requires reliable visual assessment or quantifying multiple micro-parameters; FUR with a hybrid input function may be a more feasible approach to quantifying regional metabolic rate with a known lesion position or organs of interest.