TP53 Alterations Are Associated With Poor Survival in Patients With Primary Mediastinal Nonseminoma Germ Cell Tumors

20227 citationsJournal Articlegold Open Access

Authors

Jack V. W. Bacon · University of British Columbia

Patrizia Giannatempo · Fondazione IRCCS Istituto Nazionale dei Tumori

Giovanna Cataldo · University of Campania "Luigi Vanvitelli"

Ladan Fazli · University of British Columbia

Neetu Saxena · University of British Columbia

Güliz Özgün · University of British Columbia

Maryam Soleimani

Abstract

TP53 alterations are common in PMNSGCT and are associated with reduced overall survival, potentially underlying the poor sensitivity to chemotherapy observed in these patients.

Topics & Keywords

Testicular diseases and treatments Ovarian cancer diagnosis and treatment Sarcoma Diagnosis and Treatment

UN Sustainable Development Goals

No poverty

Publication Details

Published in: The Oncologist

Volume 27, Issue 11, pp. e912-e915

DOI: 10.1093/oncolo/oyac197

Field-Weighted Citation Impact: 1.51