Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

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Authors

Kah‐Leong Lim · National Neuroscience Institute

Abstract

The intestinal expression of α-syn recapitulates many phenotypic and pathologic features of PD, and induces dysbiosis that aggravates the pathology through the DUOX-ROS-JNK pathway in Drosophila. Our findings provide new insights into the role of intestinal α-syn in PD pathophysiology.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Autism Spectrum Disorder Research Lysosomal Storage Disorders Research

Publication Details

Published in: Translational Neurodegeneration

Volume 11, Issue 1, pp. 44-44

DOI: 10.1186/s40035-022-00318-w

Field-Weighted Citation Impact: 5.73

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Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

Authors

Abstract

Topics & Keywords

Publication Details