Nb/Starch-Doped ZnO Nanostructures for Polluted Water Treatment and Antimicrobial Applications: Molecular Docking Analysis

Nb/starch-doped ZnO quantum dots (QDs) were prepared by a coprecipitation route. A fixed quantity of starch (st) and different concentrations (2 and 4%) of niobium (Nb) were doped in a ZnO lattice. To gain a better understanding of synthesized nanostructures, a systematic study was carried out utilizing several characterization methods. The goal of this research was to undertake methylene blue (MB) dye degradation with a synthetic material and also study its antibacterial properties. The phase structure, morphology, functional groups, optical properties, and elemental compositions of synthesized samples were investigated. Our study showed that ZnO QDs enhanced photocatalytic activity (PCA), resulting in effective MB degradation, in addition to showing good antimicrobial activity against Gram-negative relative to Gram-positive bacteria. Molecular docking study findings were in good agreement with the observed <i>in vitro</i> bactericidal potential and suggested ZnO, st-ZnO, and Nb/st-ZnO as possible inhibitors against dihydrofolate reductase (DHFR_{E. coli}) and DNA gyrase_{E. coli}.