Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels

2022108 citationsJournal Articlebronze Open Access

Authors

Leila Mohammadi · University of California, San Francisco

Daniel D Han · University of California, San Francisco

Fengyun Xu · University of California, San Francisco

Abel Huang · University of California, San Francisco

Ronak Derakhshandeh · University of California, San Francisco

Poonam Rao · University of California, San Francisco

Adam Whitlatch

Abstract

Chronic vaping and smoking both impair FMD and cause changes in the blood that inhibit endothelial NO release. Vaping, but not smoking, causes changes in the blood that increase microvascular endothelial permeability and may have a vaping-specific effect on intracellular oxidative state. Our results suggest a role for RAGE in e-cigarette-induced changes in endothelial function.

Topics & Keywords

Cardiovascular Health and Disease Prevention Cardiovascular Disease and Adiposity Advanced Glycation End Products research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 42, Issue 11, pp. 1333-1350

DOI: 10.1161/atvbaha.121.317749

Field-Weighted Citation Impact: 16.74