Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease

202249 citationsJournal Articlebronze Open Access

Authors

Catherine Chinhchu Lai · University of California San Diego

Bliss Nelsen · University of California San Diego

Eduardo Frías-Anaya · University of California San Diego

Helios Gallego-Gutiérrez · University of California San Diego

Marco Orecchioni · La Jolla Institute for Immunology

Victoria Herrera · University of California San Diego

Elan Ortiz

Abstract

Our study reveals previously unknown links between neuroinflammatory astrocytes and inflamed CCM endothelium as contributors that trigger leukocyte recruitment and precipitate immunothrombosis in CCM lesions. However, therapeutic approaches targeting brain endothelial NF-κB activity may contribute to detrimental side effects.

Topics & Keywords

Vascular Malformations Diagnosis and Treatment Intracranial Aneurysms: Treatment and Complications Intracerebral and Subarachnoid Hemorrhage Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 131, Issue 11, pp. 909-925

DOI: 10.1161/circresaha.122.321129

Field-Weighted Citation Impact: 5.72