Pharmacokinetic and pharmacodynamic comparison of epinephrine, administered intranasally and intramuscularly

202237 citationsJournal Articlehybrid Open Access

Authors

Sarina Tanimoto

Michael Kaliner · Institute for Asthma and Allergy

Richard F. Lockey · Florida College

Motohiro Ebisawa · National Sagamihara Hospital

Luana Pesco Koplowitz

Barry Koplowitz

Richard Lowenthal

Abstract

Intranasal delivery of epinephrine using neffy increases systolic blood pressure more efficiently than do manual intramuscular injection and epinephrine autoinjectors, despite lower maximum plasma concentrations.

Topics & Keywords

Food Allergy and Anaphylaxis Research Drug-Induced Adverse Reactions Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Allergy Asthma & Immunology

Volume 130, Issue 4, pp. 508-514.e1

DOI: 10.1016/j.anai.2022.10.024

Field-Weighted Citation Impact: 4.75