Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture

202221 citationsJournal Articlebronze Open Access

Authors

Alexander Katz · National Human Genome Research Institute

Min‐Lee Yang · University of Michigan

Michael G. Levin · Philadelphia VA Medical Center

Catherine Tcheandjieu · Gladstone Institutes

Michael R. Mathis · Michigan Medicine

Kristina L. Hunker · H3D (United States)

Susan Blackburn

Abstract

FMD and AAAs seem to be sex-dimorphic manifestations of a heritable arterial disease with a partially shared complex genetic architecture. Excess risk of having an AAA according to a family history of FMD may justify screening in family members of individuals having FMD.

Topics & Keywords

Renal and Vascular Pathologies Aortic aneurysm repair treatments Vascular anomalies and interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Genomic and Precision Medicine

Volume 15, Issue 6, pp. e003496-e003496

DOI: 10.1161/circgen.121.003496

Field-Weighted Citation Impact: 2.89